Solid Lipid Nanoparticles for Enhancement of Curcumin

Solid Lipid Nanoparticles for Enhancement of Curcumin Development and Evaluation of Solid Lipid Nanoparticles for Bioavailability Enhancement of Curcumin CHAPTER 2 LITERATURE REVIEW 2.2 LITERATURE REVIEWED ON DRUG Chirio, et.al (2011) formulated Curcumin-loaded solid lipid nanoparticles of fatty acids (FA) via coacervation technique based on FA precipitation from their sodium salt micelles in the presence of polymeric non-ionic surfactants and found higher entrapment efficiency and lowest possible cytotoxicity. Prashar, et.al (2011) studied the various biological effects and other aspects of the Curcumin, herbal remedy and dietary spice. According to them Curcumin is a lipophilic molecule and rapidly permeate cell membranes and act by inhibiting tumor cell proliferation, induction of analysis, inhibition of transformation of normal cells to tumor cells and inhibition of invasion of metastasis. A number of animal studies have shown that Curcumin has a dose-dependent chemopreventive effect in colon, duodenal, stomach, esophageal and oral carcinogenesis. Curcumin possess various other activities like anti-inflammatory, anti-cancer, anti-coagulant, anti-fibrotic, anti-mutagenic, anti-fertility, anti-bacterial, anti-diabetic, anti-protozoan, anti-viral etc and concluded that Curcumin is an effective bioactive agent. The low water solubility and poor bioavailability of Curcumin can be overcome by various structural modifications. Stability aspect shows better effect and less toxicity offering bet ter pharmacodynamic characteristics. Choudhary, et.al (2012) studied the various potential therapeutic effects of Curcumin and reported that the research towards nanoparticles encapsulated Curcumin should be strengthened to improve bioavailability and therapeutic efficacy in treatment of various disorders. Wang, et.al (2012) formulated Curcumin loaded solid lipid nanoparticles via solvent injection method using stearic acid and lecithin as lipid, tween 80 as surfactant and chloroform as cosolvent. The prepared SLNs were evaluated for various parameters like entrapment efficiency, drug loading, zeta potential, particle size, x-ray diffraction, in-vitro(via dialysis bag method) and in-vivo(in Balb/c mice) drug release and it was found that average size of C-SLNs was found to be 190 nm with zeta potential value of -20.7 mV and 75% drug entrapment efficiency. X-ray diffraction analysis revealed the amorphous nature of the encapsulated Curcumin. The release profile of C-SLLNs was an initial burst followed by sustained release and the Curcumin concentration in plasma suspension were significantly higher than those obtained with Curcumin alone, following C-SLNs, all the tissue concentrations of Curcumin increased, especially in lung and liver and it was found that in animal model of asthma, C -SLNs effectively suppressed airway hyperresponsiveness and inflammatory cell infiltration and also significantly inhibited the expression of T-helper-2-type cytokines, such as interleukin-4 and interleukin-13, in bronchoalveolar lavage fluid compared to the asthma group and Curcumin-treated group. These observations implied that C-SLNs could be a promising candidate for asthma therapy. Zheng, et.al (2013) formulated solid lipid nanoparticles to encapsulate Curcumin, by blending liquid lipids (Sefsol-218Â ®) with various solid lipids (Dynasan 114Â ®, Dynasan 118Â ®, Compritol ATO 888, Precirol 5ATO, Glyceryl monostearate, stearic acid and Hexadecanoid acid, Pluronic F68) via high pressure homogenization technique and found that the particle size decreased during the high shear process, and high pressure homogenization ensured the homogeneity of the nanoparticles. They also found that the Poloxamer 188 played a large role in the small and stable lipid nanoparticle system and contributed to the improved incorporation efficiency of Curcumin and concluded that suitable amount of liquid lipid when blended reduced the particle size of solid lipid nanoparticles and stabilized the system with improved dispensability and chemical stability in aqueous systems and exhibited sustained release and prolonged cell growth inhibition and cellular uptake in cancer cells as compare d to unformulated free Curcumin and the relative bioavailability significantly increase after intravenous administration in rats. Kakkar, et.al (2013) prepared and evaluated Curcumin loaded solid lipid nanoparticles in the experimental paradigm of cerebral ischemia (BCCAO model) in rats and found that there was an improvement of 90% in cognition and 52% inhibition of acetylcholinesterase versus cerebral ischemic group. Neurological scoring improved by 79%. Hence, study indicates protective role of Curcumin against cerebral ischemic insult; provided it is packaged suitably for improved brain delivery. Sun, et.al (2013) prepared Curcumin loaded solid lipid nanoparticles (C-SLNs) by high-pressure homogenization by blending liquid lipid Sefsol-218Â ® with the solid lipids and found that the high shear process, and high pressure homogenization ensured the homogeneity of the nanoparticles thereby improving the dispersibility and chemical stability of Curcumin, prolonging its antitumor activity and cellular uptake and enhancing its bioavailability. The morphology, sbability and release of Curcumin in the optimized formulation were investigated. The anti-cancer activity of the formulation was evaluated in MCF-7 cells. Fluorescence spectrophotometry was used to quantify cellular uptake of the drug. Blending sefsol-218Â ® into a lipid matrix reduced the particle size without improving drug loading, mean size was found to be 152.8Â ±4.7 nm and a 90% entrapment efficiency. Curcumin displayed a two-phase sustained release profile from C-SLNs with improved chemical stability, compared to th e soubilized solution, C-SLNSs exhibited prolonged inhibitory activity in cancer cells, as well as time-dependent increases in intra-cellular uptake. After inravenous administration to rats, the bioavailability of Curcumin was increased by 1.25 fold and it was concluded that C-SLNs with improved dispersibility and chemical stability in an aqueous system have been successfully developed. C-SLNs may represent a potentially useful cancer therapeutic Curcumin delivery system. Chen, et.al (2014) fabricated Curcumin loaded solid lipid nanoparticles via emulsion-evaporated technique and low temperature-solidification technique using monostearin as lipid, tween 80 as surfactant and methanol as cosolvent. C-SLNs were formed by lipid recrystallisation and the blank SLNs were prepared by the same procedure without adding Curcumin. Prepared C-SLNs were evaluated for various parameters like particle size, zeta potential, differential scanning calorimetry, x-ray diffraction, and in-vitro release and it was found that the particle size is 99.99 nm, polydispersity index of 0.158, zeta potential of -19.9 mV, and entrapment efficiency of 97.86 % and drug loading capacity of 4.35 %. The release kinetics in-vitro demonstrated Curcumin-loaded solid lipid nanoparticles can control drug-release and it was concluded that the Curcumin-loaded solid lipid nanoparticles could be prepared successfully with high drug entrapment efficiency and loading capacity and hence may be a pr omising drug delivery system to control drug release and improve bioavailability.

Essays --

BUSINESS ECONOMICS ASSIGNMENT--3 Question: 1)(a)Analyse both the conventional and unconventional tools used by central banks. Monetary policy means the measures that are adopted by the Central bank of the different nations implement in the country to achieve certain goals like: Goals of Monetary Policy- ïÆ'Ëœ Controlling Inflation: The monetary policy helps in controlling the inflation by controlling to supply of money. ïÆ'Ëœ Economic Development: It performs exceptionally viable part in pushing economic development by giving sufficient credit to gainful sectors. ïÆ'Ëœ Expand in the Rate of Employment: It has an alternate destination is to attain full job yet without increase in the inflation rate. ïÆ'Ëœ Distribution of Credit: It should additionally guarantee that appropriation of credit ought to be fair and deliberate. The credit necessity ought to be provided for backward territories. 1. Conventional Tools: ïÆ'Ëœ Change the reserves requirements that are Cash Reserve Ratio and the Statutory Liquidity Ratio: Every bank has to have a certain amount of reserves with them from the total deposits that have come in the bank this called as the statutory Liquidity ratio. And the amount of reserve that the bank needs to maintain with the central bank is called the cash reserve ratio. The central bank decides on the percentage of those reserves that the banks hold. ïÆ'Ëœ Open Market Operations:In this conventional tool the Central bank buys and sells financial assets from banks to maintain the economic stability in the country. ïÆ'Ëœ Change of its official interest rate; Bank Rate:The third conventional method that the Central Bank uses to maintain economic stability is change of its official interest rate on the loans taken by the commercial ban... ...on which will in itself require less non-renewable energies like the petroleum merchandise. CITATION- Pigou’s.L(1935) Theory Of Unemployment, Journal of Economics, 286-335 Stanley.D.M. & Warell Thomas, A( 2005) Economics For Business, UK : Prentice hall, Financial Times Press Soloman, H & Hinderston .K (2007) Regression Analysis, Quantitative Survey, Journal Of Business Surveys,299-315 Romer. (1982) Advanced Macroeconomics, New York : McGraw Hilton Alesina, K & M.Toyle(1997) Business Economics, Journal Of Business Economics, 67-89 Kuznets, H(1948) National Income: A new Version, Advanced Macroeconomics, 89, 102 Chapman, Greg.K(1997) Economics: An interactive Study Guide, Longman University: Melbourne Barzun, L(1958) Advanced Macroeconomics, Journal of Economics, 123-48 Keynes, J.M(1936) The General Theory Of Unemployment, Interest, MacMillan: London

Do You Agree with the View That, by 1882, the Concept of the ‘Angel in the House’ Had Been Overturned?

Edexcel P 29 B Type Essay 4(b) study the sources F, G and H and use your own knowledge. Do you agree with the view that, by 1882, the concept of the ‘angel in the house’ had been overturned? The angel in house concept was very popular in the 19th century and it was a custom that many wives conformed to. The ‘angel in the house’ was described by Coventry Patmore’s poem towards his wife and how he fulfilled his needs by being altruistic.Men and women also had ‘separate spheres’ which was the ideology that men should conformed to public affairs and women should conform to private affairs within the home. However, by 1882, ideology changed and more women decided that they did not only want to conform to private affairs but they should be able to be public and voice their ideas, the concept had been changed slightly, however not completely overturned as many women still conformed to the ‘angel in the house’ concept.Source F was wr itten by Caroline Norton and published in 1854. It implies that the concept had not been overturned, as she is referring to the power that her husband still contained with the custody of their children. This shows that Caroline was rebelling against the norms that a wife should have towards her husband. In Caroline’s accounts of her years married to her husband she describes that he was physically violent towards her and on many occasions family members had to get involved.Caroline speaking out towards her husband in court showed merely that she was courageous enough to rebel against the ‘angel in the house’ concept. Source G supports Caroline in a way that one of the images shows a husband being physically abusing his wife. This adds supports to Caroline as it portrays in the image the language in which Caroline uses to describe her feelings towards her husband which are negative and shocking as many women would not dare to talk about their husband in that way.S ource G challenges the concept because in 1864 there was the First Contagious Disease Act which was an act which was the need to reduce venereal diseases. This was strongly campaigned by Josephine Butler, one of the first emerging feminists. The cartoon claims ‘Is Marriage a Failure – As a rule –Yes! ’ which is ironic because it is claiming that marriage, the ballpoint of keeping society was failing, however, the concept of ‘the angel in the house’ was still being fought to stay within the household and the stronghold of keeping all women conformed to the ‘separate spheres’.Source H is from Melanie Phillips, whose perspective on the ‘angel in the house’ is viewed nostalgically. In her analysis she is able to show the ‘paradox behind the double standard’ which was shown thoroughly through the Divorce Reform, it is challenging the idea that women cannot be in the house and speaking out, voicing their ideas publically. Nevertheless, it portrays that woman are still able to be in the house and also participate publically.In conclusion, it can be argued that the ‘angel in the house’ was not overturned however women still wanted to voice their opinions and stand up for inequality even if it was in marriage which was seen as unacceptable but stay in the household supporting their family. Nevertheless the concept had been slightly changed with feminists such as Caroline Norton and Josephine Butler’s campaigns supporting women’s rights, which a century ago would seen as an abomination making a female speak out without the permission from her husband. The ‘angel in the house’ concept had been slightly changed in 1882 however not completely overturned.

Black And Black Memories And Dreams Of Girlhood Essay

The United States have a long history of painful inequality between races. Prior to 1954 the country was extremely racially divided by different laws and ways of thinking. American slavery began in the early 17th century, and continued domestically until the American Civil War. After the war, strict Jim Crow segregation laws were put into place to divide the everyday lives of white and black people. Lorraine Hansberry writes the 1959 play â€Å"A Raisin in the Sun† and tackles themes of institutionalized racism and segregation a black family experiences. She uses strong symbolism in her writing to comment on racist values and struggles experienced in post Jim Crow era Chicago by black Americans. African American feminist bell hooks’ memoir â€Å"Bone Black: Memories of Girlhood† also uses symbolism to cover the topic of segregation. Her memoir uses brief passages to highlight certain memories and dreams of hers. For this essay, I will use â€Å"A Raisin in the Sun† for the topic of residential segregation, and â€Å"Bone Black: Memories of Girlhood† for hooks’ insight on education segregation. Both authors were part of the Black Arts Movement which is the artistic branch of the Black Power Movement. The two texts remind readers that the historical and cultural conventions attached to a race do not disappear when laws are removed. Moreover, the embedded ways of thinking and the differential treatment of certain races do not automatically vanish when laws are no longer around. At the time ofShow MoreRelated Impact of Chinese Heritage on Maxine Hong Kingstons The Woman Warrior2371 Words   |  10 Pages—Maxine Hong Kingston It is true that some dream in color, and some dream in black and white. Some dream in Sonic sounds, and some dream in silence. 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